Transdifferentiation.com

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Transdifferentiation - an overview | ScienceDirect Topics

Transdifferentiation was originally defined by Okada (1991) as the conversion of one differentiated cell type into another. The original, and still the most studied, example is the conversion of pigmented epithelial cells from the iris into lens cells, which occurs during lens regeneration in newts and in cultures of pigment cells from various species (Figure 5.1b). This …

Sciencedirect.com

Transdifferentiation - Latest research and news | Nature

2021-12-16 · Transdifferentiation. Definition. Transdifferentiation is the conversion of a cell type present in one tissue or organ into a cell type from …

Nature.com

Dedifferentiation, transdifferentiation and reprogramming ...

2011-01-21 · Dedifferentiation, transdifferentiation and reprogramming could all be exploited to replace lost cells and tissues. Studies are aiming to understand the molecular details of these processes and to ...

Nature.com

SRRM4 Drives Neuroendocrine Transdifferentiation of ...

Transdifferentiation has not been established. In this study, we developed a computational tool, COMPAS, to identify an NEPC-specific AS signature of the genes that are predominantly spliced by SRRM4. Molecular and biological evidence validated these findings and demonstrated that, in the context of ARPI, SRRM4 can drive transdifferentiation to ...

Livingtumorlab.com

A Tail of Transdifferentiation

2002-12-06 · In salamanders, transdifferentiation occurs during regeneration of limbs, neural retina, and lens, but only within mesodermal or ectodermal lineages . This is the first unequivocal demonstration that an ectodermally derived stem cell, the NSC, is converted into mesodermal cell types during the regeneration of amphibian tissues. As yet unanswered is the question of …

Science.org

Dedifferentiation: A New Approach in Stem Cell Research ...

2007-09-01 · Xiaobing Fu (e-mail: [email protected]) ... Other instances of transdifferentiation include the conversion of pancreatic cells to hepatocytes (Shen et al. 2003) and of vascular endothelium to smooth muscle (Frid et al. 2002). All of these experimental findings point to a dedifferentiation–redifferentiation model rather than to direct …

Academic.oup.com

Transdifferentiation - Wikipedia

Transdifferentiation, also known as lineage reprogramming, is an artificial process in which one mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent state or progenitor cell type. It is a type of metaplasia, which includes all cell fate switches, including the interconversion of stem cells.

En.wikipedia.org

The transcription factor Zic4 acts as a ...

2021-12-23 · The molecular mechanisms that maintain cell identities and prevent transdifferentiation remain mysterious. Interestingly, both dedifferentiation and transdifferentiation are transiently reshuffled during regeneration. Therefore, organisms that regenerate readily offer a fruitful paradigm to investigate the regulation of cell fate stability. …

Biorxiv.org

transdifferentiation | biology | Britannica

Transdifferentiation, conversion of one differentiated (mature) cell type into another cell type. Transdifferentiation occurs naturally in only a few instances of regeneration.A celebrated example is the Wolffian regeneration of the lens in newts, where removal of the lens of the eye provokes the formation of a new lens derived from the cells of the iris.

Britannica.com

The clinicopathologic spectrum and genomic landscape of de ...

2021-06-21 · Dedifferentiation and transdifferentiation are rare and only poorly understood phenomena in cutaneous melanoma. To study this disease more comprehensively we have retrieved 11 primary cutaneous ...

Nature.com

Exploring the Mechanisms of Differentiation ...

2014-08-18 · We explored the underlying mechanisms of differentiation, dedifferentiation, reprogramming and transdifferentiation (cell type switchings) from landscape and flux perspectives. Lineage reprogramming is a new regenerative method to convert a matured cell into another cell including direct transdifferentiation without undergoing a pluripotent cell state …

Journals.plos.org

TGF-beta induced transdifferentiation of mammary ...

1994-12-15 · This phenotypic differentiation displays the hallmarks of an epithelial to mesenchymal transdifferentiation event. Since NMuMG cells make high levels of the type I TGF-beta receptor Tsk7L, yet lack expression of the ALK-5/R4 type I receptor which has been reported to mediate TGF-beta responsiveness, we evaluated the role of the Tsk7L receptor in …

Rupress.org

(PDF) Dedifferentiation, transdifferentiation and ...

The least common procedure in CAF differentiation is transdifferentiation (lineage reprogramming) where one mature somatic cell is converted into …

Researchgate.net

SIRT6 protects vascular smooth muscle cell from osteogenic ...

Osteogenic transdifferentiation of VSMCs serve a critical role in VC, so we explored . 17 . the potential role of SIRT6 in this process. SIRT6 reduced the expression of osteogenic . 18 . marker (osteopontin (OPN), osterocalcin (OCN)) and maintained the expression of . 19 . contractile property markers (α-smooth muscle actin (α-SMA), smooth muscle-22α . 20 (SM22α)) in vivo …

Dm5migu4zj3pb.cloudfront.net

(PDF) Loss of MyoD Promotes Fate Transdifferentiation of ...

Brown adipose tissue (BAT) represents a promising agent to ameliorate obesity and other metabolic disorders. However, the abundance of BAT decreases with age and BAT paucity is a common feature of obese subjects. As brown adipocytes and myoblasts

Academia.edu

Acute brain vascular regeneration occurs via lymphatic ...

2021-09-24 · Chen and Li et al. show that acute cerebrovascular regeneration is achieved by transdifferentiation of ingrown lymphatic vessels (iLVs), which occurs exclusively in stand-alone iLVs through Notch activation. The track iLVs retain the lymphatic nature through inhibition of Notch by EphrinB2a/EphB4a. Suppression of transdifferentiation blocks acute BV regeneration.

Cell.com

Reemployment of Kupffer's vesicle cells into axial and ...

2021-12-01 · Kupffer's vesicle (KV) in the teleost embryo is a fluid-filled vesicle surrounded by a layer of epithelial cells with rotating primary cilia. KV transiently acts as the left-right organizer but degenerates after the establishment of left-right asymmetric gene expression. Previous labelling experiments indicated that descendants of KV-epithelial cells are incorporated into …

Biorxiv.org

Transdifferentiation | definition of transdifferentiation ...

Transdifferentiation. The conversion of stem cells derived from one tissue into cells normally found in another tissue. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, or visit the webmaster's page for free fun content .

Medical-dictionary.thefreedictionary.com

Dual Fibroblast Transdifferentiation Mediated by Type I ...

Email; Print; Session Information. Date: Sunday, November 7, 2021. Session Title: Cytokines & Cell Trafficking Poster (0508–0516) Session Type: Poster Session B. Session Time: 8:30AM-10:30AM. Background/Purpose: Linking inflammation to fibrosis, a common end stage feature of many autoantibody mediated rheumatic diseases, remains a challenge. Indeed the signature …

Acrabstracts.org

JCI - SIRT6 protects vascular smooth muscle cell from ...

2021-11-18 · Email the journal; Go to. Top; Abstract; Supplemental material; Version history; PDF Metrics. Article usage; Citations to this article Advertisement Research In-Press Preview Cell biology Vascular biology Free access | 10.1172/JCI150051. SIRT6 protects vascular smooth muscle cell from osteogenic transdifferentiation via Runx2 in chronic kidney disease Wenxin …

Jci.org

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